
Vipivotide tetraxetan
CAS No. 1702967-37-0
Vipivotide tetraxetan ( PSMA-617 )
产品货号. M26397 CAS No. 1702967-37-0
Vipivotide tetraxetan 是一种高效的前列腺特异性膜抗原 (PSMA) 抑制剂(Ki 为 0.37 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥2325 | 有现货 |
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5MG | ¥3912 | 有现货 |
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10MG | ¥5597 | 有现货 |
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25MG | ¥8748 | 有现货 |
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50MG | ¥12069 | 有现货 |
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100MG | ¥15876 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Vipivotide tetraxetan
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Vipivotide tetraxetan 是一种高效的前列腺特异性膜抗原 (PSMA) 抑制剂(Ki 为 0.37 nM)。
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产品描述Vipivotide tetraxetan is a high potent inhibitor of prostate-specific membrane antigen (PSMA)(Ki of 0.37 nM).(In Vitro):Vipivotide tetraxetan demonstrated high radihigh inhibition potency, highly efficient internalization into LNCaP cells and olytic stability for at least 72 h.(In Vivo):The small-animal PET measurements showed high tumor-to-background contrasts as early as 1 h after injection of Vipivotide tetraxetan.?Organ distribution revealed specific uptake in LNCaP tumors and in the kidneys 1 h after injection of Vipivotide tetraxetan.
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体外实验Vipivotide tetraxetan (PSMA-617) demonstrates high radiolytic stability for at least 72 h. A high inhibition potency (equilibrium dissociation constant Ki=2.34±2.94 nM on LNCaP; Ki=0.37±0.21 nM enzymatically determined) and highly efficient internalization into LNCaP cells are demonstrated.
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体内实验Organ distribution with 68Ga-labeled Vipivotide tetraxetan (PSMA-617) after 1 h (n=3) reveals a high specific uptake in LNCaP tumors and in the kidneys. The high uptake in the kidneys is nearly completely blocked by coinjection of 2 mg of 2-PMPA per kilogram. Other organs such as the liver, lung, and spleen show rather low uptake and no blocking effect, with the exception of the spleen. Tumor-to-background ratios are 7.8 (tumor to blood) and 17.1 (tumor to muscle) at 1 h after injection. As compared with the 68Ga-labeled version, the organ distribution with 177Lu-labeled Vipivotide tetraxetan (PSMA-617) (n=3) show a similar uptake in the LNCaP tumors and in the kidneys. The liver uptake is found to be statistically different. Tumor-to-background ratios determined 1 h after injection show slightly higher values (tumor to blood, 22.1; tumor to muscle, 25.6) than previous organ distribution with 68Ga-labeled Vipivotide tetraxetan (PSMA-617).
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同义词PSMA-617
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number1702967-37-0
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分子量1042.154
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分子式C49H71N9O16
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (119.95 mM)
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SMILESOC(=O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CC[C@H](CNC(=O)CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)CC1)C(O)=O)C(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Feng X, Su G, Ye Y, Zhang R, Yang X, Du B, Peng B, Tu P, Chai X. Alashinols F and G, two lignans from stem bark of Syringa pinnatifolia. Nat Prod Res. 2017 Jul;31(13):1555-1560.